Ingredient research, explained clearly.
Explore research on individual ingredients and see what it does—and doesn't—tell us about this formula.
The studies below examine particular ingredients and preparations. They are not clinical trials of Testosterone + Advanced. Individual amounts for ingredients in the proprietary blend are not separately disclosed, so equivalence to study doses cannot be established.
Tongkat AliHuman study
Stress and hormone measures with a Tongkat Ali extract
Talbott et al., 2013 · Placebo-controlled study over four weeks
Reported changes in selected mood measures and salivary hormone measures over four weeks compared with placebo.
Limitation. Mixed-sex, small study of a standardized extract. Salivary outcomes and study results cannot be presented as this product’s expected blood-test change.
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- Design
- Placebo-controlled study over four weeks
- Participants
- 63 moderately stressed adults, mixed sex
- Measured outcome
- Mood measures and salivary hormone measures
- Relevance to this formula
- The Tongkat Ali amount and specification in this blend are not disclosed, so equivalence to the studied extract is not established.
- Citation
- Talbott et al., 2013
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AshwagandhaHuman study
Perceived stress with an ashwagandha root extract
Chandrasekhar et al., 2012 · Randomized, placebo-controlled trial over 60 days
Reported lower stress scores and serum cortisol with a specific root extract than with placebo.
Limitation. Particular extract and population. No dose or form equivalence to this blend is established. The same changes or timeline are not promised.
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- Design
- Randomized, placebo-controlled trial over 60 days
- Participants
- 64 adults with chronic stress
- Measured outcome
- Stress scores and serum cortisol
- Relevance to this formula
- The ashwagandha amount in this blend is not provided, and a 25:1 descriptor does not establish equivalence to the studied extract.
- Citation
- Chandrasekhar et al., 2012
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AshwagandhaHuman study
Strength and recovery during resistance training
Wankhede et al., 2015 · Randomized, placebo-controlled trial alongside a resistance-training program
Reported improvements in strength and selected recovery and body-composition measures relative to placebo.
Limitation. Training was part of the intervention. Muscle gain, fat loss, or exercise-free results are not promised from this formula.
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- Design
- Randomized, placebo-controlled trial alongside a resistance-training program
- Participants
- Men following a resistance-training program
- Measured outcome
- Strength, recovery markers, and body-composition measures
- Relevance to this formula
- The study tested a specific extract with a training program, not this combined formula.
- Citation
- Wankhede et al., 2015
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ShilajitHuman study
Testosterone measures with purified shilajit
Pandit et al., 2016 · Placebo-controlled study over 90 days
Reported changes in testosterone measures over 90 days compared with placebo.
Limitation. Purified study preparation with no matching specification or individual amount established here. This does not show that the formula corrects low testosterone.
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- Design
- Placebo-controlled study over 90 days
- Participants
- Healthy men aged 45 to 55
- Measured outcome
- Testosterone measures
- Relevance to this formula
- The shilajit in this blend has no published specification or disclosed amount.
- Citation
- Pandit et al., 2016
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ShilajitHuman study
Strength retention after a fatigue protocol
Keller et al., 2019 · Controlled study using a laboratory fatigue protocol
Examined strength retention following a laboratory fatigue protocol using a particular shilajit preparation.
Limitation. Exercise fatigue is a different endpoint from all-day energy, afternoon tiredness, or chronic fatigue. This is not an energy guarantee.
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- Design
- Controlled study using a laboratory fatigue protocol
- Measured outcome
- Strength retention after fatiguing exercise
- Relevance to this formula
- A particular preparation was studied; equivalence to the shilajit in this blend is not established.
- Citation
- Keller et al., 2019
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MacaHuman study
Self-reported sexual desire in adult men
Gonzales et al., 2002 · Randomized, placebo-controlled trial over 12 weeks
Found improved self-reported desire without a corresponding difference in testosterone versus placebo.
Limitation. Desire is not the same outcome as testosterone. The studied preparation cannot be assumed equivalent to the 40:1 ingredient described here.
Read summary
- Design
- Randomized, placebo-controlled trial over 12 weeks
- Participants
- Adult men
- Measured outcome
- Self-reported sexual desire and serum testosterone
- Relevance to this formula
- The maca amount in this blend is not disclosed, and the study did not measure this formula.
- Citation
- Gonzales et al., 2002
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FenugreekHuman study
A specialized fenugreek seed extract in men
Rao et al., 2016 · Randomized, placebo-controlled trial
Studied a specialized fenugreek seed extract for androgen-related symptoms, hormone measures, and sexual function.
Limitation. The supplied formula is not identified as containing that branded extract. Its brand name is not a product ingredient here, and its claims do not transfer.
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- Design
- Randomized, placebo-controlled trial
- Measured outcome
- Androgen-related symptoms, hormone measures, and sexual function
- Relevance to this formula
- The fenugreek in this blend has no disclosed specification or amount.
- Citation
- Rao et al., 2016
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Fadogia AgrestisAnimal research
Testicular-function measures in male rats
Yakubu et al. · Animal research
Evaluated testicular-function measures in male rats given a Fadogia Agrestis extract.
Limitation. Animal research. It does not establish human benefit, a safe human amount, or long-term safety.
Read summary
- Design
- Animal research
- Participants
- Male rats
- Measured outcome
- Testicular-function measures
- Relevance to this formula
- No human evidence for this ingredient is included here.
- Citation
- Yakubu et al.
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BoronIngredient overview
Boron: health-professional fact sheet
NIH Office of Dietary Supplements · Ingredient overview, not a clinical trial
Summarizes what is known about boron and where the evidence stands.
Limitation. Background reading on the trace element, not a trial of this product.
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- Design
- Ingredient overview, not a clinical trial
- Measured outcome
- Summary of boron intake, sources, and research
- Relevance to this formula
- Boron’s presence does not establish a free-testosterone result from this formula.
- Citation
- NIH Office of Dietary Supplements
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